منابع مشابه
Transcriptional Regulation of Axon Pathfinding
different species and neuron types. Some are candi-† Neuron dates for being direct regulators of the molecules that Cell Press confer pathfinding specificity. In each system dis-Cambridge, Massachusetts 02138 cussed, the projection phenotypes of the neurons involved had been described previously so that alterations in pathfinding were easily recognized. Neuronal differentiation has been postula...
متن کاملZebrafish mutations affecting retinotectal axon pathfinding.
We have isolated mutants in the zebrafish Danio rerio that have defects in axonal connectivity between the retina and tectum. 5-day-old fish larvae were screened by labeling retinal ganglion cells with DiI and DiO and observing their axonal projections to and on the tectum. 82 mutations, representing 13 complementation groups and 6 single allele loci, were found that have defects in retinal gan...
متن کاملSemaphorin and neuropilin co-expression in motoneurons sets axon sensitivity to environmental semaphorin sources during motor axon pathfinding.
Class III semaphorins (SemaIIIs) are intercellular cues secreted by surrounding tissues to guide migrating cells and axons in the developing organism. This chemotropic activity is crucial for the formation of nerves and vasculature. Intriguingly, SemaIIIs are also synthesized by neurons during axon pathfinding, but their function as intrinsic cues remains unknown. We have explored the role of S...
متن کاملEngrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons.
During early development, multiple classes of interneurons are generated in the spinal cord including association interneurons that synapse with motor neurons and regulate their activity. Very little is known about the molecular mechanisms that generate these interneuron cell types, nor is it known how axons from association interneurons are guided toward somatic motor neurons. By targeting the...
متن کاملFacial visceral motor neurons display specific rhombomere origin and axon pathfinding behavior in the chick.
In the chick embryo, facial motor neurons comprise branchiomotor and visceral motor subpopulations, which innervate branchial muscles and parasympathetic ganglia, respectively. Although facial motor neurons are known to develop within hindbrain rhombomere 4 (r4) and r5, the precise origins of branchiomotor and visceral motor neuron subpopulations are unclear. We investigated the organization an...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2010
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a001735